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#researchers

1 post1 participant0 posts today
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LabPlot

@LabPlot at the service of #science and #researchers! 🔬 👩‍🔬 ⚗️

@labplot@lemmy.kde.social @opensource @openscience @organic_chemistry @ChemistryViews

#LabPlot is a FREE, open source and cross-platform Data Visualization and Analysis software.

We're pleased to know that #LabPlot was used to perform calculations in this recent study on robust access to furo-fused #heteropolycycles:

👉 mdpi.com/1420-3049/30/4/948

MDPIAn Appealing, Robust Access to Furo-Fused HeteropolycyclesRecently, nitrostilbenes characterized by two different or differently substituted aryl moieties, obtainable from the initial ring-opening of 3-nitrobenzo[b]thiophene with amines, have proved, by means of a stepwise double coupling with phenolic-type bidentate C/O nucleophiles, to be valuable precursors of oxygen-containing heteropolycycles and of fully conjugated systems therefrom via an efficient 6π-electrocyclization and final aromatization. Herein, the methodology is extended, after suitable optimization, to diverse heterophenols to afford new appealing heteropolycyclic systems of potential interest as drug leads. The synthetic results are fully consistent with up-to-date quantomechanical calculations. For some of the new molecules, a significant fluorescence is reported, with a potential for future applications, e.g., in the field of optical devices.
#Research#OpenScience#Chemistry
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LabPlot

#LabPlot at the service of #science and #researchers!

@labplot@lemmy.kde.social

Boosts appreciated! :boost_love:🚀

We're pleased to know that #LabPlot was used in this recent study on ceftazidime-avibactam (CZA) tolerance/persistence:

▶️ link.springer.com/article/10.1

SpringerLinkCeftazidime-avibactam tolerance and persistence among difficult-to-treat KPC-producing Klebsiella pneumoniae clinical isolates from bloodstream infections - European Journal of Clinical Microbiology & Infectious DiseasesPurpose Tolerance and persistence occur “silently” in bacteria categorized as susceptible by antimicrobial susceptibility testing in clinical microbiology laboratories. They are different from resistance phenomena, not well-studied, and often remain unnoticeable. We aimed to investigate and characterize ceftazidime-avibactam (CZA) tolerance/persistence in 80 Klebsiella pneumoniae isolates from bloodstream infections. Methods We used the Tolerance Disk Test (TDtest) to detect CZA tolerance/persistence and investigate the avibactam (AVI) influence on them, and time-kill assays with minimal duration for killing (MDK) determination to characterize/differentiate CZA tolerance from persistence, for selected isolates. Whole genome sequencing was performed for 49/80 selected isolates to investigate genes related to beta-lactam tolerance/persistence and resistance as well as phylogeny studies. Results Tolerance/persistence to CZA was detected in 48/80 (60%) isolates, all extensively drug-resistant (XDR) or multidrug-resistant, carbapenem-resistant K. pneumoniae (CRKp), KPC producers, and previously categorized as susceptible (not resistant) to CZA. No heteroresistance was detected. CZA tolerance/persistence occurred due to ceftazidime tolerance/persistence and was not related to AVI in the CZA combination. 5/11 isolates were characterized as CZA-tolerant and 5/11 as CZA-persistent. The single (1/11) XDR and CRKp non-KPC producer was truly susceptible. All the CZA-tolerant/persistent isolates (ST11, ST258, ST340, ST437, ST16, ST17, and ST307) harbored the carbapenemase-encoding gene blaKPC−2. Mutation in only two genes (rpoS and degQ) related to beta-lactam tolerance/persistence was found in only 7/49 CZA-tolerant/persistent isolates, suggesting the presence of yet unknown beta-lactam tolerance/persistence genes. Conclusion Among the K. pneumoniae bloodstream isolates studied, 60%, previously categorized as susceptible to CZA, were, actually, tolerant/persistent to this antibiotic, all these KPC producers.
#Research#Medicine#Physiology
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Krononaut Moon 🌕 2025 Mar 14

The #KrononautMoon Project seeks to make contact with #TimeTravelers — i.e., extradimensional beings — by promoting decentralized community experiments during the #TotalLunarEclipse. There will be 3 #TLEclipses in the next 2 years. The first of the triad occurs next month on 2025 Mar 14, the night of the #FullMoon & March's #WormMoon. All are invited (even skeptics) to celebrate on Thursday or Friday evening under the stars — wherever you are.

🔗 KronoMoon.org 🔗 Medium.com/write-under-the-moo
🔗 Wikipedia.org/wiki/Time_travel 🔗 Pushkin.fm/podcasts/the-last-a

@KronoMoon on #Mastodon shares toots, articles & videos on various sub-themes and sub-theories, because any theory of #TimeTravel is polydimensional, beyond our current technology, and incomplete. Often associated with #UFOs or #UAP, a real-life encounter with a #spacetime ship or a #TimeMachine is less likely than some kind of #quantum #signal. It's possible that such signals have been beaming toward us for a long time. Please take lots of #photos of the #Moon and share them with @KronoMoonPhotos, so that we can document any anomalous phenomena. The plan focuses on Lunar Eclipses that are "Total" (typically occurring about once per year) and not other types of Eclipses.

@KronoMoon toots use a variety of #hashtags:

• #Muticultural #Multilingual #Community #Connections & #Empathy
(because we need to peacefully coexist with others)
#native #aborigine #indigenous #intersectional #FirstPeople #POC #BLM #PWD #DEI #LGBTQ+ 🏳️‍🌈

• #Philosophy & #Spirituality
#consciousness #mindbody #dualism

• #Microcosm & #Macrocosm
#quantumphysics #higherdimensions #topology #astronomy #basicresearch #cosmology

• #QuantumEntanglement & #Wormholes
#darkmatter #darkenergy #manyworlds

• #SciFi & #Speculative #Fiction
#movies #books #spokenword

• #Experimental & #Conceptual #Arts
#film #performance #dance #drumcircles

• #UAP #Ufology & #Alien #Intelligence
#experiencers #whistleblowers #researchers

• #Time #Timelessness & #TimeTravel
#entropy #evolution #ancient #history #migrations #fossils #cavepaintings #myths #stonecircles

• #Observation & #Documentation
#research #media #reporting #photo #digital #archives

The Krononaut Moon ProjectThe Krononaut Moon ProjectCommunity Time Travel Research since 1982 Mar 09. 🏳️‍🌈 ☮️
#MoonOverMastodon#Comments#Welcome
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UniversityofGroningenLibrary

New University of #Groningen Press publication 🥳

➡️ Spinoza’s #Yoga: Practice of #Power and Experience of the Infinite
🔗 books.ugp.rug.nl/ugp/catalog/b

#University of Groningen Press is an #OpenAccess publisher, providing a publishing platform for #journals, #books and series, inaugural lectures and open textbooks by #teachers and #researchers working at or with the #University of Groningen.
rug.nl/research/ugp/

book cover
#Spinoza#philosophy
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UniversityofGroningenLibrary

🥳 The #Dutch #Diamond #OpenAccess Expertise Center is now live!

🔗 openaccess.nl/en/diamond-open-

The center aims to reinforce and future-proof the Netherlands' #DiamondOA #publishing landscape.
It serves as a knowledge hub connecting #researchers, publishers, #librarians, #policymakers, and #funders.

🤩 We're excited to be a partner with our University of Groningen Press.

www.openaccess.nlAbout | Open Access
#ScholarlyCommunication#OpenScience
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UniversityofGroningenLibrary

🐱 A study by @universityofgroningen #researchers of #Dutch #cat owners reveals:

Many of them anthropomorphize their pets, attributing #human #social roles like family member or #child.

➡️ "Cat owners’ anthropomorphic perceptions of feline emotions and interpretation of photographs"

This can lead to misinterpreting #feline emotions and behaviours by projecting complex human-like social and emotional characteristics onto cats.

🔗 sciencedirect.com/science/arti

#OpenAccess#caturday#CatsOfMastodon
Continued thread
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UniversityofGroningenLibrary

What do #researchers at our university say about #DiamondOA initiatives they support or work with?

"The scholar-led journal 'Demographic Research' by the @maxplanckgesellschaft is a gem in the world of #demography. With its commitment to diamond open access, exceptional variety of content, and a peer review process that rivals the best, it's a great pick for all fellow demographers."

Read all testimonials
🔗 rug.nl/library/open-access/dia

Graphic highlighting International Open Access Week themed 'Community over Commercialization', featuring a photo and a testimonial (quote in the toot) by Prof. Dr. Clara Mulder emphasizing the quality of the "Demographic Research" journal.
#OAWeek#OpenScience
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